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KMID : 0043319990220030324
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Archives of Pharmacal Research
1999 Volume.22 No. 3 p.324 ~ p.326
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Inhibitory Activity of Monoamine Oxidase by Coumarins from Peucedanum japonicum
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Dang Thi Lan Huong
Rho Tae-Cheol
Lee Hyun-Sun
Lee Myung-Koo
Kim Young-Ho
Choi Hee-Cheol
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Abstract
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Four coumarins were isolated from chloroform extract of the root of Peucedanum japonicum and identified as praeruptorin A (1), xanthotoxin (2), psoralen (3) and bergapten (4) on the basis of spectroscopic methods. The inhibitory activities of these coumarins on monoamine oxidase prepared by mouse brian were tested. The IC50 values of them were shown to be (1), (2), (3), and (4), in vitro.
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KEYWORD
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Peucedanum japonicum, Umbelliferae, Coumarins, Monoamine oxidase
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